Relationale: Conversations with Culture Changers - Manuel Quezon, III

Game Changers

The evolution of musculoskeletal ultrasound as a tool in the daily practice of the rheumatologist has been astounding. Its benefits include relative lack of expense and the capability to carry out dynamic joint assessment 1. Whereas plain radiographs demonstrate established bony damage, ultrasound can highlight ongoing synovial inflammation, nonradiographic bony erosion and soft tissue patholog...

Game Changers

Hepatic encephalopathy (HE) is an impairment of cognition and/or consciousness affecting up to 70% of patients with cirrhosis. Whilst overt encephalopathy (OHE) is associated with a reduction in life expectancy, minimal encephalopathy (MHE) is known to effect quality of life, social interaction and driving capacity. Previously control of HE was restricted to identification and management of pot...

Game changers

Metastatic SCC of the neck is frequently seen, however occasionally the primary site is not identified. Gone are the days of the ‘blanket biopsy’ of tonsil, tongue base, larynx, bronchus and oesophagus. Although PET can aid in pinpointing the primary tumour location, there still exist a number of patients with a true ‘unknown primary’. Part of any cancer service is follow-up, after treatment, t...

Game Changers

The cyclical structure of this molecule has been previously employed in various industries: In low fat dairy spreads, hydrophobic cholesterol is removed using a process by lodging it inside the cyclodextrin. Hydroxypropyl-β-cyclodextrin (HPβCD) is the principle active compound in the fabric odour eliminator Febreze, the cyclodextrin simply envelops any malodorous molecules leaving even my runni...

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